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Part of our Prostate 911 overview. Last checked October 27, 2026.
The Prostate 911 supplement is a 2-capsule daily prostate formula from PhytAge Laboratories, and its safety has never been studied as a finished product. Most risk sits in a 142 mg proprietary blend: it includes goldenseal, which raised blood levels of a test drug by about 62% in a 14-day human study[4], and uva ursi, which trials used only for 5 days[6].
What is the Prostate 911 supplement, and is it safe?
Nobody has measured its safety, and the vendor's safety wording goes further than the evidence. The FAQ calls it "as safe as a daily multi-vitamin" and "safe to use for healthy men and women"[2]. No study backs that statement for this product.
The disclosed ingredients, such as saw palmetto, plant sterols and pygeum, had mild side effects in trials. NCCIH describes saw palmetto as well tolerated, with occasional digestive upset, dizziness or headache[10].
The open questions come from items with undisclosed amounts: goldenseal and drug interactions, uva ursi and long-term use, and diuretic herbs such as buchu and juniper. Men who take prescription medicines, and anyone pregnant or breastfeeding, should not rely on the vendor's wording as a safety check.
What do the label and safety facts show?
The label gives the dose, the allergen line and the full ingredient list, but no product-specific warning study sits behind it. Here are the facts we recorded from the vendor label on October 27, 2026[1].
| Label or safety point | What it says or shows | Why it matters |
|---|---|---|
| Directions | "adults take two capsules daily" | No timing or food guidance |
| Allergen line | "Contains soy (plant sterols)" | Avoid with a soy allergy |
| Capsule | Gelatin (bovine) | Not vegetarian |
| Goldenseal | Inside 142 mg blend, amount hidden | Inhibits CYP3A and CYP2D6 in humans[5] |
| Uva ursi | Inside 142 mg blend, amount hidden | Releases hydroquinone; short courses only[6] |
| Green tea extract | 50 mg | Rare liver injury from extract capsules[14] |
| Selenium | 140 mcg, 200% DV | Count other supplements toward the 400 mcg upper limit[15] |
| Vitamin B6 | 3.33 mg | EFSA set a 12 mg adult limit; check multivitamins[16] |
Goldenseal and drugs cleared by CYP enzymes
In 16 healthy adults, 14 days of goldenseal raised midazolam exposure from 107.9 to 175.3 ng*h/mL and stretched its half-life from 2.0 to 3.2 hours[4]. A 28-day study found about 40% inhibition of the CYP2D6 and CYP3A4/5 enzymes[5]. Those enzymes clear many drugs, including some statins, calcium channel blockers, antidepressants, opioids such as codeine and tramadol, and tamoxifen.
Those studies used about 3 g a day. Prostate 911's whole blend is 142 mg, so its goldenseal dose is far lower, and whether that amount affects drug levels is unknown. NCCIH also advises against goldenseal in pregnancy and breastfeeding[3].
Uva ursi: how long is too long?
Uva ursi was tested for urinary infections in 5-day courses[6]. It converts to hydroquinone in the body. A case of bull's-eye eye damage was reported after 3 years of use[7], and severe low blood sodium followed a uva ursi "kidney detox" tea taken with heavy fluid intake[8]. No study covers small daily amounts for months. The vendor FAQ suggests at least 90 days[2], and the largest bundle is 120 days, far beyond the trial courses. Avoid it in pregnancy and breastfeeding[9].
Saw palmetto and PSA tests
Saw palmetto does not appear to change PSA readings, even at high doses[10]. In the CAMUS trial, PSA rose 0.23 ng/mL on saw palmetto and 0.16 ng/mL on placebo, a non-significant gap[11]. That is different from finasteride and dutasteride, which lower PSA, so doctors use a lower cutoff for men on them[12]. A normal PSA while taking Prostate 911 is not a sign it is working, and the supplement is no reason to skip a PSA test.
Other cautions in the formula
- Cat's claw (30 mg): NCCIH lists possible interactions with blood thinners and blood pressure drugs, and a bleeding risk around surgery[13].
- Graviola (50 mg): regular soursop tea was tied to atypical parkinsonism in Caribbean studies[17].
- Gravel root (in the blend): its plant family contains pyrrolizidine alkaloids that can harm the liver[18].
- Diuretic herbs: buchu, juniper and uva ursi are traditional diuretics. NIDDK lists diuretic medicines among drugs that can worsen BPH symptoms[19].
What should you check before buying, and when do you need a doctor?
Check your medicines and your symptoms first. Then weigh the refund terms on our Prostate 911 legitimacy check.
- Show the full label, including the blend, to a pharmacist if you take any prescription drug, especially statins, heart or blood pressure drugs, antidepressants, opioids, blood thinners or tamoxifen.
- Tell your doctor you take it, and keep any prescribed BPH medicine, such as an alpha blocker or a 5-alpha reductase inhibitor[19].
- Skip it if you are pregnant or breastfeeding, have liver or kidney disease, or have a soy allergy.
- Add up B6, selenium and zinc from any multivitamin you also take.
- Tell your surgeon you take it before any operation, because NCCIH notes cat's claw may slow blood clotting[13].
See a doctor right away if
- you have trouble urinating or cannot urinate at all
- you see blood in your urine
- you have fever or chills with urgent, painful urination
- you have severe lower belly pain, or fever with flank pain, which can mean a kidney infection[19][6]
Urinary symptoms can come from BPH, infection, prostatitis or prostate cancer, so a supplement should not delay that visit.
Our take
Prostate 911's disclosed ingredients were mild in trials, but its "multi-vitamin" safety line skips real questions. Our evidence cards rate uva ursi and gravel root as ones to avoid in a daily, open-ended formula, and goldenseal as one to avoid with CYP-cleared drugs, and the label hides all three amounts. If you take prescription drugs, clear it with a pharmacist first. For the evidence on benefit, see does Prostate 911 work; for dosing, see how to take Prostate 911.
Back to the Prostate 911 overview.
Frequently asked questions
Is Prostate 911 safe to take with blood pressure medicine?
Ask a pharmacist first. Goldenseal in the blend inhibited liver enzymes that clear some calcium channel blockers in human studies, and NCCIH lists possible cat's claw interactions with blood pressure drugs. The goldenseal amount in Prostate 911 is not disclosed.
Can women take Prostate 911?
The vendor FAQ says it is safe for healthy men and women, with no study behind that. Goldenseal and uva ursi should be avoided in pregnancy and breastfeeding, according to NCCIH and LactMed, and the formula targets the prostate.
Does Prostate 911 affect a PSA test?
Its saw palmetto is unlikely to. NCCIH says saw palmetto does not appear to change PSA readings, and the CAMUS trial found no difference from placebo. Tell your doctor about every supplement before a PSA test anyway.
Can I take Prostate 911 with finasteride or tamsulosin?
Only after asking your doctor. No study has tested Prostate 911 with BPH drugs. Never stop a prescribed BPH medicine to switch to a supplement, and mention the goldenseal in the blend when you ask.
Does Prostate 911 contain caffeine?
The label does not list caffeine. It includes 50 mg of green tea leaf extract, and NCCIH notes green tea contains caffeine, but the caffeine amount in that extract is not stated on the label.
Sources
- Prostate 911 Supplement Facts label image. Prostate 911 vendor, read October 27, 2026.
- Prostate 911 FAQ. Prostate 911 vendor page, read October 27, 2026.
- Goldenseal. NCCIH (NIH), read October 27, 2026.
- Goldenseal and midazolam pharmacokinetics in healthy volunteers. PubMed, read October 27, 2026.
- Goldenseal and CYP2D6 and CYP3A4/5 activity in healthy volunteers (Gurley 2005). PubMed, read October 27, 2026.
- Uva ursi vs fosfomycin for uncomplicated urinary tract infection (REGATTA trial). PubMed, read October 27, 2026.
- Bull's eye maculopathy after long-term uva ursi use. PubMed, read October 27, 2026.
- Severe hyponatremia after a uva ursi detox tea. PubMed, read October 27, 2026.
- Uva Ursi (LactMed). National Library of Medicine, read October 27, 2026.
- Saw Palmetto: Usefulness and Safety. NCCIH (NIH), read October 2, 2026.
- Effect of saw palmetto extract on serum PSA (CAMUS analysis). Journal of Urology, 2013, read October 2, 2026.
- Prostate-Specific Antigen (PSA) Test. National Cancer Institute, read October 2, 2026.
- Cat's Claw. NCCIH (NIH), read October 27, 2026.
- Green Tea. NCCIH (NIH), read October 2, 2026.
- Selenium Fact Sheet for Health Professionals (archived copy). NIH Office of Dietary Supplements, read October 20, 2026.
- Scientific opinion on the tolerable upper intake level for vitamin B6. EFSA Journal, 2023, read October 2, 2026.
- Annonaceae herbal tea use and atypical parkinsonism in Caribbean patients. PubMed, read October 27, 2026.
- Pyrrolizidine alkaloids in Eupatorium species (Colegate 2018). PubMed, read October 27, 2026.
- Enlarged Prostate (Benign Prostatic Hyperplasia). NIDDK (NIH), read October 2, 2026.
This page is general information, not medical advice. Dietary supplements are not reviewed by the FDA for safety or effectiveness before they are sold and are not intended to diagnose, treat, cure or prevent any disease. Talk to your doctor before taking any supplement, especially if you are pregnant, nursing, take medication or have a health condition.
